TIM-3 is a regulator of both innate and adaptive immunity in patients with myeloid diseases.3
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TIM-3 expression on immune cells promotes the immune dysfunction associated with disease complexity4
For instance, macrophages have increased TIM-3 expression and do not release cytokines, thus promoting immune tolerance
AML, acute myeloid leukemia; HR-MDS, higher risk MDS; TIM-3, T cell immunoglobulin and mucin domain-3.