Watch Dr Platzbecker discuss the role of TIM-3 in immune dysfunction
- “TIM-3 may be an interesting target for immuno-myeloid therapy in higher-risk MDS and AML.”
—Uwe Platzbecker, MD, PhD - TIM-3 may play an important role in immune dysfunction1,2
- Addressing TIM-3 expression may help reawaken immune function
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Uwe Platzbecker, MD, PhD, Director of Medical Clinic I,
Hematology and Cell Therapy University Hospital, Leipzig, Germany
TIM-3 is expressed on dysfunctional immune cells involved in innate and adaptive immunity1,3
T Cell
(Immune Cell)
NK Cell
(Immune Cell)
Macrophage
(Immune Cell)
Dendritic Cell
(Immune Cell)
Monocyte
(Immune Cell)
TIM-3 expression may play a critical role in the suppression of cells involved in innate and adaptive immunity4-8
- TIM-3 is expressed on exhausted T cells, can impair NK cells and DCs, and is associated with dysfunctional macrophages and monocytes4-8
- This may cause immune cells to be unable to kill LSCs and blasts
TIM-3 is also expressed on LSCs and blasts, but not on healthy hematopoietic stem cells2
Leukemic Blast Cell
Leukemic Stem Cell
Healthy Stem Cell
- There is evidence that TIM-3 delivers proliferative signals when expressed on MDS blasts9
- TIM-3 signaling may be critical for the maintenance of AML10
TIM-3 expression has been associated with disease severity and progression to AML9,10
- TIM-3 expression levels increase from low-risk MDS to high-risk MDS to AML9
- Data suggest that TIM-3 signaling may play a critical role in progression of MDS to AML10