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Can addressing immune dysfunction help close the treatment durability gap in HR-MDS and AML?

Can addressing immune dysfunction help close the treatment durability gap in HR-MDS and AML?

Can addressing immune dysfunction help close the treatment durability gap in HR-MDS and AML?

Can addressing immune dysfunction help close the treatment durability gap in HR-MDS and AML?

Watch Dr Komrokji discuss present and possible future treatments for HR-MDS and AML

 
  • Current treatment options offer limited durability and short median durations of response1,2
  • With few treatment advances, patients with HR-MDS remain at risk for transformation to AML3
  • “An immunotherapeutic approach for myeloid diseases, or immuno-myeloid therapy, may be a promising way to address immune dysfunction”
    —Rami Komrokji, MD
 
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Rami Komrokji, MD, Vice Chair,
Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL

 

“An immunotherapeutic approach for myeloid diseases, or immuno-myeloid therapy, may be a promising way to address immune dysfunction”
—Rami Komrokji, MD

  • An immuno-myeloid approach harnesses the immune system to eliminate malignant myeloid cells in patients with HR-MDS and AML
LEARN MORE ABOUT HOW TIM-3 MAY BE A KEY PLAYER IN HR-MDS AND AML

 

Current treatments offer limited durability and short median durations of response1,2

  • Median duration of response is ~13 months with HMAs in patients with HR-MDS and 17.5 months with an HMA/BCL-2 combination in patients with AML1,2
  • OS is as low as 9.6 months in patients with HR-MDS with a very high-risk IPSS-R score and is <12 months in patients with AML3-5
  • Longer durations of HMA treatment have shown better outcomes, but only 37% of patients remain on therapy for <12 courses6
CAN FOCUSING ON TIM-3 EXPRESSION ADDRESS IMMUNE DYSFUNCTION?

 

With few treatment advances, patients with HR-MDS remain at risk for transformation to AML3

1 in 4 patients will develop AML after a median duration of 8.8 to 16.7 months
1 in 4 patients will develop AML after a median duration of 8.8 to 16.7 months
 
  • 1 in 4 patients will develop AML after a median duration of 8.8 to 16.7 months3
CAN ADDRESSING TIM-3 EXPRESSION BRING ABOUT NEW ADVANCEMENTS IN TREATMENT?

 

 

Learn more about the treatment durability gap by hearing Dr Wei discuss the limitations of current treatments for HR-MDS and AML

 
Andrew Wei, MBBS, PhD, Cancer Agency Research Fellow and Hematologist,
Alfred Hospital at Monash University, Australia
 

AML, acute myelogenous leukemia; BCL-2, B-cell lymphoma 2; DC, dendritic cell; HMA, hypomethylating agent; HR-MDS, higher-risk myelodysplastic syndromes; IPSS, International Prognostic Scoring System; NK, natural killer; OS, overall survival; PFS, progression-free survival; TIM-3, T cell immunoglobulin and mucin domain-3.

 
References: 1. Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol. 2009;10(3):223-232. 2. DiNardo CD, Jonas BA, Pullarkat V, et al. Azacitidine and venetoclax in previously untreated acute myeloid leukemia. New Engl J Med. 2020;383(7):617-629. 3. Greenberg PL, Tuechler H, Schanz J, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood. 2012;120(12):2454-2465 4. Kantarjian HM, Thomas XG, Dmoszynska A, et al. Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia. J Clin Oncol. 2012;30:2670-2677. 5. Dombret H, Seymour JF, Butrym A, et al. International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts. Blood. 2015;126(3):291-299. 6. Cabrero M, Jabbour E, Ravandi F, et al. Discontinuation of hypomethylating agent therapy in patients with myelodysplastic syndromes or acute myelogenous leukemia in complete remission or partial response: retrospective analysis of survival after long-term follow-up. Leuk Res. 201;39(5):520-524.
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